Wholesale Effective Cooling Agent Manufacturer & Manufacturers

Expert Physiological Cooling Compounds, High-Purity Synthetics & Premium Botanical Extracts for Global Food, Cosmetics, and Oral Care Solutions

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Deep-Dive Technical Whitepaper

The Physiology of Cooling: Activating the TRPM8 Sensory Pathway

In industrial flavoring, personal care, and therapeutic formulations, the sensory perception of "coolness" plays an essential psychological role. Traditional cooling molecules, predominantly L-menthol, achieve this sensory activation by physically interacting with the Transient Receptor Potential Melastatin 8 (TRPM8) ion channel—a temperature-sensitive receptor located on sensory neurons. Upon activation, the channel permits an influx of calcium ions, generating an action potential that the central nervous system interprets as a cooling sensation.

However, pure menthol possesses significant chemical disadvantages, including high volatility, a sharp, medicinal odor, skin irritation at higher concentrations, and low thermal stability. As a leading wholesale effective cooling agent manufacturer, Jiangxi Hairui Natural Plant Co., Ltd. supplies high-purity synthetic and plant-derived derivatives (such as WS-3, WS-23, and botanical terpenes) engineered to target the TRPM8 pathway selectively. These advanced physiological agents provide a clean, long-lasting cooling effect devoid of the undesirable aromatic and irritant footprints associated with crude menthol.

Cooling Agent Thermosensate Power Odor Profile Thermal Threshold
WS-3 Strong, lingering local cooling Virtually odorless Up to 220°C
WS-23 Sharp, immediate burst No minty aroma Up to 180°C
Menthyl Lactate Gentle, moisturizing cool Faint herbal-sweet Moderate
Natural L-Menthol Immediate, high intensity Strong mint odor Highly volatile (<50°C)
Featured Compounds

Hot-Sale Industrial Additives & Botanical Oils

Natural sea buckthorn fruit oil

Natural sea buckthorn fruit oil, plan...

Appearance: Light Yellow Liquid
Odour: Rich, sweet and sour berry aroma
Highly concentrated therapeutic phytochemicals.

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Wholesale WS-3 Food Grade

Wholesale WS-3 Food Grade Effective C...

Appearance: White crystalline powder
Purity: ≥99% CAS 39711-79-0
Excellent stability and cooling profile.

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Wholesale Water-Soluble Natural Chlorophyll

Wholesale Water-Soluble Natural Chlor...

Appearance: Dark green liquid
Odour: Odorless natural botanical colorant and nutrient additive.

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Production Capabilities

Diverse Raw Material Categorization

Essential Oil 1 Essential Oil 2
01

Essential Oil

Usually extracted by steam distillation or cold compression. Highly stable raw materials like camellia, eucalyptus, oregano, and peppermint oil. Hairui implements rigorous raw material selection processes to ensure superior sensory quality.

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Base Oil 1 Base Oil 2
02

Base Oil

Also known as medium or carrier oil, usually extracted by cold compression. Since single essential oils cannot be rubbed directly on the skin, they must be diluted in a high-grade carrier oil. We extract a premium range of vegetable oils.

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Herbal Extract 1 Herbal Extract 2
03

Herbal Extract

Herbal extracts are separated cleanly from plant matrices using modern extraction techniques. Supported by our 5,000+ acre self-owned raw material production base, guaranteeing excellent quality control from seed to delivery.

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High-Purity Organic Synthesis

The Chemistry of Advanced Thermosensates: WS-3 and WS-23 Synthesis

Modern commercial cooling requirements demand compounds that can withstand thermal processes like extrusion, pasteurization, and baking without degrading or evaporating. Traditional cooling methods fail at these high temperatures, necessitating the use of synthetic cooling agents like carboxamides and alkyl-substituted amides.

1. Cooling Agent WS-3 (N-Ethyl-p-menthane-3-carboxamide)

WS-3 is derived from menthol-3-carboxylic acid. Through a series of reaction steps including chlorination and ethylamination, it is refined into a highly pure crystalline structure. WS-3 exhibits intense cooling activity primarily targeting the roof of the mouth and the tongue. Because of its high threshold of activation, it remains stable up to temperatures of 220°C, making it the preferred choice for high-heat confectionery and pharmaceutical tablet manufacturing.

2. Cooling Agent WS-23 (2-Isopropyl-N,2,3-trimethylbutyramide)

Unlike WS-3, WS-23 is not structurally derived from menthol. Its acyclic structure permits a unique sensory pathway that avoids any trace of typical minty undertones. Formulators utilize WS-23 for its rapid, front-of-mouth cooling burst, which provides immediate sensory impact. Its low volatility, high solubility in glycol carriers, and thermal stability up to 180°C make it a standard cooling molecule in modern oral care, functional beverages, and vape formulations.

Corporate Overview

About Hairui Natural Plant Co., Ltd.

Founded in 2006, Jiangxi Hairui Natural Plant Co., Ltd. is a high-tech enterprise specializing in the R&D, production, and global export of premium natural plant essential oils, carrier bases, and advanced synthetic cooling compounds. Strategically located in the Jinggang Mountain High-Tech Development Zone, Ji'an, our location provides convenient access to the region's rich botanical resources.

Covering an area of 13,000 square meters, our facility is equipped with state-of-the-art gas chromatography (GC-MS), high-performance liquid chromatography (HPLC), and advanced distillation apparatus. With a total investment of 50 million RMB, we maintain a production capacity of 2,000 tons of natural plant extracts per year, supplying formulators in over 56 countries and regions.

17+

Years Experience

2000

Tons Production Capacity

18M

USD Capitalization / Investment

56+

Countries and Regions Served

What we offer icon

What We Offer

Hairui Natural Plant only offers natural, safe, effective, and scientifically backed products that are manufactured and tested through rigorous quality control procedures.

What we do icon

What Do We Do

Hairui Natural Plant has invested abundant resources on the upgrading of QA/QC standards and innovation levels, improving our core competitiveness on quality control and R&D.

Why work with us icon

Why Work With Us

From strict raw material selection to final delivery testing, our 9-step quality control process ensures premium quality and quick support for optimized solutions.

Global Procurement Integration

Procurement Demands and Technical Integration of Cooling Agents

B2B procurement of cooling agents requires balancing physiological performance, regulatory compliance, and formulation stability. Modern chemical sourcing teams look beyond price per kilogram; they prioritize reliable technical specifications and consistent delivery protocols.

1. Solvent Compatibility & Solubility

Formulators often struggle with the poor solubility of crystalline cooling agents in aqueous systems. WS-3, for example, is insoluble in water but highly soluble in ethanol, propylene glycol, and natural essential oils. Selecting the proper carrier matrix is critical to preventing recrystallization, which can cause gritty textures in cosmetics or uneven cooling spots in foods and oral care products.

2. Sensory Synergies with Natural Botanical Oils

Combining synthetic molecules like WS-23 with natural cooling agents, such as peppermint essential oil, yields a well-balanced sensory profile. The natural terpenes in peppermint oil provide an immediate cooling burst, while the synthetic molecules extend the duration of the sensation for up to 30 minutes without the bitter aftertaste associated with high concentrations of natural menthol.

3. Modern Extraction and Purification

Our extraction facility utilizes advanced vacuum molecular distillation to isolate pure natural molecules without high-heat degradation. This process ensures our cooling compounds and essential oils retain their natural structure, reducing the need for synthetic stabilizers in final formulations.

  • Zero Pesticide Residue: Verified through advanced chromatography.
  • No Synthetic Contaminants: Guaranteed raw materials.
  • Heavy Metal Compliance: Tested below international safety thresholds.
Industry Solutions

Focus on Industrial Application Solutions

Essential oils and active cooling compounds are utilized across diverse industries, from agricultural pest control to premium cosmetics, high-performance pharmaceuticals, and aromatherapeutics.

Agriculture

In Agriculture: Natural Pesticides, Herbicides & Fungicides

Sweet orange oil, a natural terpene extract, is an eco-friendly pesticide and adjuvant. It promotes crop leaf respiration and photosynthesis while effectively controlling pests and diseases, offering clear economic and environmental benefits.

Cosmetics

In Cosmetics & Daily Chemicals: Hair & Skin Care Formulas

Castor oil, rich in ricinoleic acid, helps moisturize hair, support scalp health, and add shine. Our range of cooling compounds provides a soothing, long-lasting cooling sensation in body lotions, shampoos, and shaving creams.

Healthcare

In the Healthcare Industry: Softgels, Capsules & Topicals

Evening primrose oil, high in GLA, is widely used in nutritional capsules to support cardiovascular health. Crystalline cooling compounds like WS-3 are also incorporated into lozenges and topical pain-relief patches to soothe target areas.

Aromatherapy

In Aromatherapy: Burners, Diffusers & Spa Products

Pure botanical extracts interact with the olfactory system to support stress relief and emotional balance. Specific essential oils are selected for their calming, sleep-supporting, or refreshing properties, depending on the formulation needs.

Global Regulatory Compliance

E-E-A-T Framework: Technical Quality Assurance & Compliance

In global B2B procurement, product quality and safety are non-negotiable. Sourcing teams require verified documentation to meet strict international standards, ensuring all ingredients are safe and compliant for consumer use.

Traceable Supply Chain

Our raw materials are sourced from our 5,000+ acre cultivation base under strict agricultural standards, ensuring full traceability from the soil to the final delivered batch.

Analytical Testing

Every batch undergoes GC-MS and HPLC testing to confirm compound identity, purity, and active concentration levels, with detailed certificates of analysis (CoA) provided.

Regulatory Registration

Our manufacturing processes comply with major international certifications, ensuring our ingredients meet FDA, FEMA, and REACH requirements for trouble-free import.

Verified Certifications

Authorized System Certificates

Certificate 1
Certificate 2
Certificate 3
Certificate 4
Technical FAQ

Expert Q&A on Cooling Agents

What are the main differences between WS-3 and WS-23 in formulations?
WS-3 is derived from menthol and provides a long-lasting, deep cooling sensation concentrated at the back of the mouth and throat. WS-23 is an acyclic compound that delivers a rapid, clean cooling burst at the front of the mouth and tongue, with no residual minty flavor. Many formulators combine them to achieve a balanced, full-mouth cooling profile.
Can synthetic cooling agents withstand high manufacturing temperatures?
Yes. Crystalline cooling agents like WS-3 and WS-23 are far more stable than natural menthol. WS-3 remains stable up to 220°C, and WS-23 stands up to 180°C. This thermal stability makes them ideal for applications involving high heat, such as hard candy extrusion, baking, and pasteurization.
How do you dissolve cooling agent powders in liquid bases?
While these powders have very low solubility in water, they dissolve easily in organic solvents like ethanol, propylene glycol, and liquid flavor oils. We recommend pre-dissolving the powder in one of these carriers before introducing it into your aqueous phase to ensure uniform distribution.
Do your cooling agents meet international food safety requirements?
Yes, our products are manufactured to food-grade standards and carry major international certifications, complying with FDA, FEMA, and REACH guidelines. We provide complete regulatory documentation and certificates of analysis (CoA) with every shipment.
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